Evaluation of the treatment efficacy by incrementally increasing dosage of cow's milk on patients with lactose intolerance

Evaluation of the treatment efficacy by incrementally increasing dosage of cow's milk on patients with lactose intolerance - The lactose intolerance treatment by incrementally increasing dosage of cow's milk

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

JPRN

Registry ID

JPRN-UMIN000023298

Enrollment

Registered

2016-07-22

Start date

2016-07-22

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Lactose Intolerance

Interventions

After screening by questionnaire survey and agreement to informed consent for the patients with abdominal symptoms due to diary consumption, a single blind comparative study is conducted by observing

s milk with an interval of 1 week or longer. Eligible patients with abdominal symptoms only due to cow&#39

s milk from the above study have lactose tolerance test and be taken their stool samples prior to the following treatment for lactose tolerance acquirement. Treatment for lactose tolerance acquiremen

s milk (lactose) intolerance from definitive diagnosis starts with small dosage (30ml) of cow&#39

s milk around the same time each day on an empty stomach. If there was no abdominal symptom, the dosage is increased by 30ml with 4 days interval. If the symptoms presented, the same amount is kept fo

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: 1.Out-patients in the department of pediatrics, Tokyo Wemens Medical University, Medical Center East and study subjects recruited from collaborative institutes 2.Patients with abdominal symptoms due to cow's milk consumption

Exclusion criteria

Exclusion criteria: 1.Patients with cow's milk allergy 2.Patients with Chronic digestive diseases, hematologic diseases, endocrine/metabolic diseases, and psycho-neurologic diseases 3.Pregnant or expected female patients 4.Other patients that the research director considers to be unsuitable in the study.

Design outcomes

Primary

Measure	Time frame
Changes in severity of abdominal symptoms before and after the treatment (8 weeks maximum) by continuing incremental increase of cow's milk load for certain period.	—

Secondary

Measure	Time frame
1.Ratio of abdominal symptoms (such as psychogenic causes) in single blind comparative study on cow's milk and lactose-reduced milk 2.Ratio of true lactose intolerance from the result of lactose tolerance test 3.Changes in before and after the treatment listed below Lactose tolerance test and intestinal bacterial flora	—

Countries

Japan

Contacts

Public ContactKazuko Okada

Tokyo Women's Medical University, Medical Center East the department of pediatrics

k.okada-med@nifty.com03-3810-1111

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026

Evaluation of the treatment efficacy by incrementally increasing dosage of cow&#39;s milk on patients with lactose intolerance