Effect on intestinal bacterial flora of the proton pump inhibitor in the nonsteroidal antiinflammatory drug chronic administration

Effect on intestinal bacterial flora of the proton pump inhibitor in the nonsteroidal antiinflammatory drug chronic administration - The effect that combination of NSAID and PPI gives to enteric bacteria

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

JPRN

Registry ID

JPRN-UMIN000023293

Enrollment

Registered

2016-07-30

Start date

2016-09-01

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

NSAIDs induced small intestinal injury

Interventions

A group (esomeprazole 20mg/day).We obtain 5 g of stool .180 days after .90 days later assignment 30 days before assignment later and measure enteric bacteria by the T-RFLP method. B group in (vonopra

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: PPI that continued NSAIDs and LDA, and took and an H2 receptor blocker or older

Exclusion criteria

Exclusion criteria: patients with a serious complication [hepatic disorder, renal disease, heart disorder, blood disorder, metabolic disorders or malignant tumor] is pregnant or hope for pregnancy during study period with the history allergic to PPI and nursing mother and others, a researcher are inadequacy and the patients who judged it

Design outcomes

Primary

Measure	Time frame
change of the intestinal bacterial flora	—

Countries

Japan

Contacts

Public ContactToshihisa Takeuchi

Osaka Medical Collage Depertment of 2nd. internal medicine

in2097@osaka-med.ac.jp0726831221

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026