Imaging and epigenetic study for the therapeutic mechanism of ECT in the treatment of referactory depression

Imaging and epigenetic study for the therapeutic mechanism of ECT in the treatment of referactory depression - Imaging and epigenetic study of ECT

Status

Recruiting

Phases

Unknown

Study type

Interventional

Source

JPRN

Registry ID

JPRN-UMIN000023198

Enrollment

Registered

2016-07-25

Start date

2013-10-01

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Refractory depression

Interventions

Electoric convulsive therapy (Twice/week, Total 10 times, Duration 5 weeks)

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: Patients with major depression diagnosed by DSM-V and MINI. They did not respond to appropriate antidepressant treatments.

Exclusion criteria

Exclusion criteria: Patients with major depression and other psychiatric disorders. Patients with major organic brain disorders. Patients who did not met ECT criteria due to physical illness.

Design outcomes

Primary

Measure	Time frame
Hamilton rating scale for depression Functinal connectivity analysis DNA methylation Outcome measurement is done 1 day and 3 months after the final ECT.	—

Countries

Japan

Contacts

Public ContactShigeru Morinobu

Kochi University Dept. Neuropsychiatry, Med. Sch.

smorinob@kochi-u.ac.jp088-880-2359

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026