Healthy adults
Conditions
Interventions
Ingestion of the plum extract-processed food (30 g) daily for 12 weeks
Ingestion of the placebo food (30 g) daily for 12 weeks
Sponsors
Hokkaido Information University
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. Subjects whose hospital SBP is >=130 mmHg and <160 mmHg. 2. Subjects who agree to participate in the current study with a written informed consent.
Exclusion criteria
Exclusion criteria: 1. Subjects who are under treatment and medication for hypertension. 2. Subjects with serious cerebrovascular, cardiac, hepatic, renal, and / or gastrointestinal diseases, or affected with an infectious disease which is required to report to the authorities. 3. Subjects who have a major surgical history related to digestive system such as gastrectomy, gastrorrhaphy, enterectomy, etc. 4. Subjects with unusually high and/or low blood pressure or abnormal hematological data 5. Subjects with serious anemia. 6. Pre- or post-menopausal subjects having complaints of obvious physical changes. 7. Subjects who are at risk of having allergic reactions to drugs or foods (especially plum, fruits of the family Rosacea and/or white birch pollen). 8. Subjects regularly take medicine, functional foods and/or supplements (peptide, acetic acid, GABA, geniposidic acid, flavonoids, sesamin, chlorella, olive leaves, garlics, dietary fiber, tomatoes, folic acid, long pepper extract, etc.) which would affect the blood pressure. 9. Heavy smokers, alcohol addicts or subjects with irregular lifestyle. 10. Subjects who donated either 400ml whole blood within 12 weeks (men) /16 weeks (women) or 200ml whole blood within 4 weeks or blood components within 2 weeks prior to this study. 11. Subjects who are pregnant or expected to be pregnant, or lactating during the study. 12. Subjects who participate in other clinical trials within the last one month prior to the current clinical trial. 13. Any other medical reasons judged by the principal investigator.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| systolic pressure and diastolic pressure at 4 weeks, 8 weeks and 12 weeks after the beginning of ingestion of test meals and at 2 weeks after the end of ingestion of test meals | — |
Secondary
| Measure | Time frame |
|---|---|
| peripheral blood flow, TC, HDL-C, LDL-C, TG, fasting plasma glucose, HbA1c, platelet aggregation, defecation frequency, VAS questionnaire | — |
Countries
Japan
Contacts
Public ContactDir. Prof. Jun NISHIHIRA, M.D., Ph.D.
Hokkaido Information University Center of Health Information Science
Outcome results
None listed