Evaluation of the effect of epidural anesthesia on aute lung injury induced by one lung ventilation in patients undergoing lobectomy for lung cancer

Evaluation of the effect of epidural anesthesia on aute lung injury induced by one lung ventilation in patients undergoing lobectomy for lung cancer - The effect of epidural anesthesia on acute lung injury induced by one lung ventilation

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

JPRN

Registry ID

JPRN-UMIN000023139

Enrollment

Registered

2016-07-21

Start date

2016-08-01

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

lung cancer

Interventions

Epidural anesthesia using 0.25% levobupivacain during one lung ventilation in patients undergoing lung resection surgeries for lung cancer Continouos intravenous infusion of remifentanyl (0.5-1.0 micr

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: Patients with ASA status 1 or 2 over 20 years old, who was scheduled for lung resection surgery

Exclusion criteria

Exclusion criteria: Heart disease with NYHA 2-4 PaO2 less than 60mmHg under room air FEV1.0% less than 50% Platelet count less than 100000/mm3 Coagulation disorder (PT-INR > 1.5)

Design outcomes

Primary

Measure	Time frame
The concentration of IL-6 in epithelial lining fluid (ELF) of respiratory tract mucosa	—

Secondary

Measure	Time frame
The concentrations of other inflammatory cytokines (TNF-alpha, IL-1beta, IL-8, IL-10) in ELF, plasma cytokine (TNF-alpha, IL-1beta, IL-6, IL-8, IL-10) and malondialdehyde concentrations, blood gas analysis, postoperative pulmonary complications and organ injuries, postoperative pain evaluated by numerical rating scale, and the length of hospital stay	—

Countries

Japan

Contacts

Public ContactTakeshi Suzuki

Keio University School of Medicine Department of Anesthesiology

takeshi-su@a7.keio.jp03-3353-1211

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026