Clinical significance of diffusion MRI in patients with moyamoya disease

Clinical significance of diffusion MRI in patients with moyamoya disease - diffusion MRI of moyamoya disease

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

JPRN

Registry ID

JPRN-UMIN000023082

Enrollment

200

Registered

2016-07-12

Start date

2015-12-22

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

moyamoya disease (children and adults)

Interventions

None listed

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: (1) inclusion criteria of patients: 1. 6 to 64 years old who can undergo MRI without sedative agents 2. diagnosed as bilateral or unilateral moyamoya disease according to diagnostic guidelines 3. no neurological deficit affecting the scores of neurophysiological tests (aphasia, agnosia etc) 4. modified Rankin scale of 0 to 3 5. informed consent obtained from patients and parents of patients under age (2) inclusion criteria of normal healthy volunteers: 1. 20 to 64 years old 2. no neurological deficit affecting the scores of neurophysiological tests (aphasia, agnosia etc) 3. modified Rankin scale of 0 to 3 4. no history of neurological disease

Exclusion criteria

Exclusion criteria: 1. patients with quasi-moyamoya disease 2. contraindication of MRI examination 3. brain lesion other than moyamoya disease affecting MRI parameters (e.g. brain tumor, venous angioma) 4. judged as inappropriate participants by doctor-in-charge

Design outcomes

Primary

Measure	Time frame
1. Comparing diffusion MRI parameters (ADC, FA, Vic, Viso and OD of NODDI) with scores of neurophysiological tests( WISC or WAIS, WCST, stroop test, word fluency test, TMT, and the BIg Five Personal Inventory or NEO-FFI)	—

Secondary

Measure	Time frame
2. Comparing diffusion MRI (ADC, FA, Vic, Viso and OD of NODDI) of patients with moyamoya disease and of age-sex matched normal healthy volunteers. 3. Comparing diffusion MRI(D* and f map of IVIM, and ADC, FA, Vic, Viso and OD of NODDI) and 15Ogas PET (CBF, CBV, OEF and CMRO2).	—

Countries

Japan

Contacts

Public ContactShoko Hara

Tokyo Medical and Dental University Department of Neurosurgery

shara.nsrg@tmd.ac.jp03-3813-6111

Outcome results