Centrally located stage I non-small-cell lung cancer
Conditions
Interventions
Carbon-ion radiotherapy 68.4GyRBE/12fractions
Sponsors
Ion Beam Therapy Center, SAGA-HIMAT Foundation
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1)Pathologically confirmed NSCLC 2)Clinically T1-T2aN0M0 diagnosed by imaging examinations including FDG-PET 3)No history of thoracic irradiation 4)Medically inoperable or refuse surgery 5)Exist of lesion for evaluation 6)Centrally located 7)No history of chemotherapy within 2 weeks 8)20 year-old or > 20 year-old 9) PS(ECOG)0-2 10)Estimated survival longer than 6 months 11)Writtened informed consent
Exclusion criteria
Exclusion criteria: 1)Interstitial pneumonitis on CT images 2)< SpO2 94% 3)Severe infections in treatment area 4)Coexisting malignancies within 2 years excepting Carcinoma in Situ, stgae I laryngeal cancer, localized prostate cancer 5)Pregnancy 6)Unfit due to mental disorders 7)Continuouslly oral or intravenous administration of steroid 8)Other reasons judged by physician
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 3-year local control rate | — |
Secondary
| Measure | Time frame |
|---|---|
| 3- and 5-year overall survival rate 3- and 5-year cause-specific survival rate 3- and 5-year progression-free survival rate Toxicities Pulmonary function (VC, FEV1.0) at 3 years | — |
Countries
Japan
Contacts
Public ContactYoshiyuki Shioyama
Ion Beam Therapy Center, SAGA-HIMAT Foundation Department of Radiation Oncology
Outcome results
None listed