Diabetes
Conditions
Interventions
None listed
Sponsors
Japan Agency for Medical Research and Development
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: Diabetes patient group: 1. Out patients with type 2 diabetes mellitus at Shiga University Hospital from August 2016 to May 2017 2. Aged 60 years to 79 years old 3. BMI 18 or more and less than 35 Non-diabetic patient group: Control subjects who are normal glucose level, visiting Shiga University Hospital for dyslipidemia, hypertension, and obesity. 1. Out patients with hypertension, dyslipidemia, and obesity at Shiga University Hospital from August 2016 to May 2017 2. Age 60 years old to 79 years old 3. BMI 18 or more and less than 35 The definition of the non-diabetic group is subject without diabetic medications and without past or current history of diabetes or with HbA1c < 6.0 within one year.
Exclusion criteria
Exclusion criteria: 1. drug that affects the energy balance (thyroid drugs, beta-blockers, GLP-1R agonist) 2. agents that influence to affect the metabolism of water (diuretics, SGLT2 inhibitors) 3. pregnancy, those in nursing 4. Those who surgery is scheduled 5. cancer, a patient being treated with arthritis 6. history of surgery that affect the food intake and absorption 7. persons within six months from the initial visit 8. with impaired physical activity (orthopedic disease, stroke, heart disease) 9. patients with severe diabetes complications 10. myositis, muscle disease patient, such as muscular dystrophy 11. Frequent (more than 5 days /week) muscular labor for more than one hour a day 12. Others attending physician was deemed inappropriate
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The difference of energy consumption per body weight between diabetic and non-diabetic patients, measured with the doubly labeled water method. | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. the difference between the diabetic and non-diabetic patients in total energy expenditure and basal metabolic rate per body weight by doubly labeled water method and indirectly calorimetry. 2. the difference among the diabetic treatment group in total energy expenditure and basal metabolic rate per body weight by doubly labeled water method and indirectly calorimetry. 3. the difference between the diabetic and non-diabetic patients in energy balance (dietary records - brief-type diet history questionnaire(BDHQ) - total energy consumption by doubly labeled water method) 4. the difference between the diabetic and non-diabetic patients in physical activity measured by the activity monitor. 5. the interrelationship between the diabetic and non-diabetic patients in physical activity measured by physical activity questionnaire. 6. the difference between the diabetic and non-diabetic patients in muscle mass and skeletal muscle cell volume. 7. the relationship among glucosuria, 1.5-AG and energy gap | — |
Countries
Japan
Contacts
Public ContactMasaya Sasaki
Shiga University Hospital Clinical Nutrition
Outcome results
None listed