Dementia Mild cognitive impairment
Conditions
Interventions
fMRI and NIRS measurements during the emotional task, MRS measurements during the resting state, and neuropsychological test
Sponsors
Preeminent Medical Photonics Education & Research Center, Hamamatsu University School of Medicine
Hamamatsu Medical Photonics Foundation
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. Healthy participants aged 20 to 29 years (young), aged 65 to 74 years (elderly) 2. Individuals who have no history of psychiatric disease 3. Individuals who are right-handed 4. Individuals who are consent to participate in this study 5. Critetria for elderly subject: 1) Individuals with Mini-mental state examination scores over 26 at screening, 2) Individuals with Clinical dementia rating scale score 0, 3) Individuals whose ADL is normal without any memory problems
Exclusion criteria
Exclusion criteria: 1. Individuals who have a history of traumatic brain injury with an unconsciousness lasting more than 5 minutes 2. Individuals who have a history of organic brain disease 3. Individuals who have a history of psychiatric disease 4. Individuals who have a history of substance dependence 5. Individuals who are taking central nervous system stimulants 6. Individuals who have a history of disorders of consciousness and/or seizure 7. Individuals who have a chronic headache 8. Individuals who have a risk for MRI scan 9. Criteria for elderly subject: 1) Individuals who have one or multiple following diagnosis: dementia (AD, FTLD, DLB), MCI, brain damage (cerebral infarction, brain hemorrhage, head trauma), Parkinsonism, Parkinson syndrome, corticobasal degeneration, 2) Individuals who have one or multiple following symptoms or disease: hearing difficulty, impaired vision, finger tremor, disease of cervical spine, cervical injury, neck pain
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Brain activations (BOLD signal changes, hemoglobin concentration changes) and brain chemistry concentrations, such as GABA and Glx levels | — |
Secondary
| Measure | Time frame |
|---|---|
| Correlations between neuroimaging data (BOLD signal changes, hemoglobin concentration changes and brain chemical substances) and neuropsychological test scores | — |
Countries
Japan
Contacts
Public ContactYumi Oboshi
Hamamatsu University School of Medicine Department of Innovative Medical Photonics
Outcome results
None listed