Analysis of association among quadriceps femoris muscle anatomy, knee extension strength and cartilage destruction in patients with knee osteoarthritis.

Analysis of association among quadriceps femoris muscle anatomy, knee extension strength and cartilage destruction in patients with knee osteoarthritis. - Analysis of association among quadriceps femoris muscle anatomy, knee extension strength and cartilage destruction in patients with knee osteoarthritis.

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

JPRN

Registry ID

JPRN-UMIN000023025

Enrollment

Registered

2016-11-04

Start date

2016-11-08

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Knee osteoarthritis

Interventions

Patients with osteoarthritis: Ultrasonography, Magnetic resonance imaging, Biochemical characteristics, Muscle strength, physical examination (height, body mass, lower limb length), Japanese Knee Oste

Eligibility

Sex/Gender

Female

Inclusion criteria

Inclusion criteria: Patients diagnosed as knee osteoarthritis by X-ray examination, who are able to walk with or without assistive devices (Kellgren-Lowrence scale2, 3). Control: healthy volunteers (no self-reported history of knee pain)

Exclusion criteria

Exclusion criteria: heart disease (myocardial infarction, angina pectoris, cardiac insufficiency), cerebrovascular disease (cerebral infarction, hemorrhage), extreme hypertension (systolic blood pressure /<=180 mmHg; diastolic blood pressure /<=110 mmHg), dementia, tumor Patients with a history or diagnosis of following disorders were excluded: lower limb or back surgery, anterior cruciate ligament injury, meniscal lesions of the knee

Design outcomes

Primary

Measure	Time frame
Ultrasonography: muscle thickness, pennation angle	—

Secondary

Measure	Time frame
Magnetic resonance imaging: muscle volume, muscle cross-sectional area Biochemical characteristics: cartilage oligomeric matrix protein (COMP) Muscle strength: knee extension strength height, body mass, lower limb length, age, Japanese Knee Osteoarthritis Measure (JKOM)	—

Countries

Japan

Contacts

Public ContactMaeda Hisashi

Graduate School of Medicine, Nagoya University Program in Integrated Medicine

maeda.hisashi@nagoya-u.ac.jp052-788-5927

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026