preterm infants
Conditions
Interventions
Attending physician explains about this research to the parents at birth. After written informed consent is obtained, each neonate is randomly assigned to the colostrum or placebo group in a 1:1 ratio
s colostrum using aseptic techniques. Then syringes are labeled, covered with opaque tape, placed in prelabeled cups and stored at 4degrees Celsius in refrigerator for exclusive use. Oropharyngeal col
s incubator for 5 minutes. Nurse places the syringe on the patient'
s right or left buccal mucosa, and administer the colostrum toward the posterior oropharynx slowly (for at least 10 seconds).Pulse oxygen saturation, respiratory rate, pulse rate, and blood pressure c
Sponsors
Okayama University
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: Neonates born before 32 weeks gestation in our NICU are enrolled.
Exclusion criteria
Exclusion criteria: Infants meet the exclusion criteria which is discribed below are excluded 1.Infant who can't obtain colostrum within 72hours 2.Infants with congenital malformations 3.Infants with chromosomal abnormalities
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Reactive oxygen metabolite, Biological anti-oxygen potential of day3(before colostrum administration), 7(after colostrum administration), 14 | — |
Secondary
| Measure | Time frame |
|---|---|
| length of accomplishment of enteral alimentation(>100ml/kg/day), body weight gain, length of hospitalization, carriage rate of MRSA, prevalence of septicemia, serum IgA | — |
Countries
Japan
Contacts
Public ContactYosuke Washio
Okayama University hospital Pediatrics
Outcome results
None listed