Evaluation of the correlation between serum carnitine and constipation

Evaluation of the correlation between serum carnitine and constipation - Evaluation of the correlation between serum carnitine and constipation

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

JPRN

Registry ID

JPRN-UMIN000022859

Enrollment

Registered

2016-06-25

Start date

2015-01-01

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

carnitine defeciensy, constipatin\on

Interventions

Supplementation with 10-50 mg/kg/day carnitine (P&lt

0.001). No other changes of medication were made during the supplementation period.

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: Patients with severe motor and intellectual disabilities were defined as having an inability to move by themselves and IQ <35

Exclusion criteria

Exclusion criteria: The patients with infection or prescribed with antibiotics

Design outcomes

Primary

Measure	Time frame
First, we examined the correlation between level of free carnitine and severity of constipation. Second, we compared the constipation group with the non-constipation group in terms of age, sex, BMI, bed rest period (years), use of anti-epileptic drugs, use of valproate sodium, use of enteral nutrition, recurrent pulmonary infection (more than twice a year), presence of pressure ulcer, and results of blood tests for nutritional assessment (including serum levels of albumin, pre-albumin, total cholesterol, free carnitine, folic acid, and the trace elements Cu, Fe, Se, and Zn). Blood samples were collected in all cases during times when there were no observed inflammation reactions and no prescribed antibiotics. Carnitine levels also were obtained from patients without motor and intellectual disabilities who had severe chronic constipation requiring disimpaction with an enema on a daily basis. Third, we compared the frequency of defecation and the form of feces before and after therapeutic supplementation with carnitine.	—

Measure

Time frame

First, we examined the correlation between level of free carnitine and severity of constipation. Second, we compared the constipation group with the non-constipation group in terms of age, sex, BMI, bed rest period (years), use of anti-epileptic drugs, use of valproate sodium, use of enteral nutrition, recurrent pulmonary infection (more than twice a year), presence of pressure ulcer, and results of blood tests for nutritional assessment (including serum levels of albumin, pre-albumin, total cholesterol, free carnitine, folic acid, and the trace elements Cu, Fe, Se, and Zn). Blood samples were collected in all cases during times when there were no observed inflammation reactions and no prescribed antibiotics. Carnitine levels also were obtained from patients without motor and intellectual disabilities who had severe chronic constipation requiring disimpaction with an enema on a daily basis. Third, we compared the frequency of defecation and the form of feces before and after therapeutic supplementation with carnitine.

—

Countries

Japan

Contacts

Public ContactShinya Murata

Hirakata City Hospital, Department of Pediatrics,

wildwind1980@live.jp072-847-2821

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026