Defining a novel law of glucose homeostasis under Dapagliflozin usage by mathematical model approach

Defining a novel law of glucose homeostasis under Dapagliflozin usage by mathematical model approach - Defining a novel law of glucose homeostasis under Dapagliflozin usage by mathematical model approach

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

JPRN

Registry ID

JPRN-UMIN000022794

Enrollment

100

Registered

2016-08-31

Start date

2016-12-08

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

type 2 diabetes mellitus

Interventions

One hundred person&#39

s time series boold glucose value or hormons concentration data, which were obtained immediately after taking SGLT2 inhibitor.

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: Type 2 diabetes mellitus who has not been administered SGLT2 inhibitors 2) 20-75 years old, 3) having a will to attend this study

Exclusion criteria

Exclusion criteria: 1) pregnant or breast-feeding women 2) insulin antibody positive (>10 arbitrary unit) 3) having allergy or skin trouble for oral hypoglycemic agants or insulin 4) type 1 diabetes or other specific type of diabetes 5) severe liver dysfunction (transaminase twice over the normal limit) 6) severe renal dysfunction (eGFR < 50) 7) severe heart failure (NYHA>2) 8) long-acting insulin, long-acting GLP-1 RA, or long-acting DPP-4 inhibitor user 9) psychological disorder 10) recent severe hypoglycemia or hypoglycemia unawareness 11) contraindication of dapagliflozine 11) others inappropriate for this study

Design outcomes

Primary

Measure	Time frame
Finding a new blood glucose homeostasis law	—

Countries

Japan

Contacts

Public ContactKazuhiko Sakaguchi

Kobe University Graduate School of Medicine Division of Diabetes and Endocrinology Department of Internal Medicine

kzhkskgc@med.kobe-u.ac.jp81-76-382-5861

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026