Healthy volunteers, mild hyperuricemia
Conditions
Interventions
Subjects receive 4 capsules (1200 mg)/day containing ume paste and ginger powder for 12 weeks.
Subjects receive 4 placebo capsules (1200 mg)/day for 12 weeks.
Sponsors
Hiroshima University
Eligibility
Sex/Gender
Male
Inclusion criteria
Inclusion criteria: Serum uric acid 6.0-7.9 mg/dL
Exclusion criteria
Exclusion criteria: 1) Taking anti-hyperuricemic drugs 2) History of gouty arthritis, gouty node, and/or gouty attack 3) Taking medicines or receiving health guidance for hypertension, diabetes, hyperlipidemia, and/or metabolic syndrome 4) Taking drugs or functional food that may affect serum uric acid level 5) Participation in any clinical trial within 90 days of the commencement of the trial 6) CKD stage >=A2 and/or >=G3a 7) History of severe disease and/or major surgery 8) Judged as ineligible by clinical investigators.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Serum uric acid level at baseline, 4, 8, and 12 weeks. | — |
Secondary
| Measure | Time frame |
|---|---|
| Uric acid clearance and urinary pH at baseline, 4, 8, and 12 weeks. Platelet aggregation test, thromboxane B2, and MDA (malondialdehyde) levels at baseline and 12 weeks. | — |
Countries
Japan
Contacts
Public ContactFumiko Higashikawa
Hiroshima University, Institute of Biomedical & Health Sciences Project Research Center for Clinical Trial and Preventive Medicine
Outcome results
None listed