Insomnia
Conditions
Interventions
Administer Suvorexant 20 mg - Wash out (more than 2 days) - Administer Brotizolam 0.25 mg - Wash out (more than 2 days) - Administer placebo (lactose)
Administer Suvorexant 20 mg - Wash out (more than
Sponsors
University of Tsukuba Faculty of health and sport sciences
International Institute for Integrative Sleep Medicine (IIIS)
Eligibility
Sex/Gender
Male
Inclusion criteria
Inclusion criteria: 1)Healthy men aged 18-40years old 2)Standard body size(BMI < 25 kg/m2) 3)Free from subjective sleep complaints (PSQI < 6 points) 4)Free from medical history of Sleep apnea syndrome 5)Participants who do not take sleeping pills 6)Participants whose sleep latency are 10 minutes or less 7)Morning people (MEQ > 59 points) 8)Habitual exercise 2 times or less a week for the past 6 months 9)Habitual drinking less than 3 times a week 10)No habitual smonking
Exclusion criteria
Exclusion criteria: 1)Participants who are taking a pill to inhibit CYP3A 2)Acute angle crose glaucoma 3)Myasthenia gravis
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The executive function 90 minutes after taking a pill (Stroop color-word test) | — |
Secondary
| Measure | Time frame |
|---|---|
| The physical functions 90 minutes after taking a pill (Balance ability, dexterity, reaction time, walking ability) Polysomnography (Sleep latency, sleep architecture) | — |
Countries
Japan
Contacts
Public ContactTomohiro Okura
University of Tsukuba Faculty of Health and Sport Sciences
Outcome results
None listed