Association between Genetic Polymorphisms of Core Clock Genes and 24-hour IOP-related profile in Japanese Normal-Tension Glaucoma

Association between Genetic Polymorphisms of Core Clock Genes and 24-hour IOP-related profile in Japanese Normal-Tension Glaucoma - Association between core clock genes and 24hr IOP related profile in Japanese NTG

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

JPRN

Registry ID

JPRN-UMIN000022741

Enrollment

100

Registered

2016-06-24

Start date

2016-07-01

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Normal tension glaucoma

Interventions

The IOP-related profile will be measured using a contact lens sensor (CLS, SENSIMED Triggerfish

Sensimed AG, Lausanne, Switzerland) in the eye with the greater visual field defect based on mean deviation value. Genotyping of polymorphisms of core clock genes (BMAL1, CLOCK, PER1, PER2, PER3, CRY

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: Subjects will be Japanese patients diagnosed with normal tension glaucoma (NTG) in the Department of Ophthalmology, Kanazawa University Hospital, Kanazawa, Japan. All the subjects included in this study will be off antiglaucoma medication treatment for at least 4 weeks before the diurnal intraocular pressure (IOP) measurements in this study.

Exclusion criteria

Exclusion criteria: Patients with systemic administration of alpha or beta-adrenergic antagonists or history of ocular surgery except for cataract extraction will be excluded.

Design outcomes

Primary

Measure	Time frame
Genetic polymorphisms of core clock genes and 24-hour IOP related profile	—

Countries

Japan

Contacts

Public ContactTomomi Higashide

Kanazawa University Graduate School of Medical Sciences Department of Ophthalmology

eyetomo@med.kanazawa-u.ac.jp0762652403

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026