Efficacy of ultrasound-guided pulsed radiofrequency treatment on the saphenous nerve in knee osteoarthritis patients with refractory knee pain: A Randomized, double-blinded, pracebo-controlled trial

Efficacy of ultrasound-guided pulsed radiofrequency treatment on the saphenous nerve in knee osteoarthritis patients with refractory knee pain: A Randomized, double-blinded, pracebo-controlled trial - Efficacy of ultrasound-guided pulsed radiofrequency treatment for refractory knee pain in knee osteoarthritis patients

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

JPRN

Registry ID

JPRN-UMIN000022736

Enrollment

100

Registered

2016-06-15

Start date

2016-08-08

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

refractory knee pain in knee osteoarthritis

Interventions

Ultrasound-guided pulsed radiofrequensy to the saphenous nerve (4.5V,2Hz,42 degree C for 8 minutes) placebo (0.3V electrical stimulation to the saphenous nerve with 2Hz currnet for 8 minutes)

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: Eligible patients were 1. male or female, 45-85 years of age 2. diagosed with radiologic tibiofemoral osteoarithritis (Kellgren-Lawrence grade 2-4) 3. with anterior-medial knee pain of moderate intensity or greater for 3 months ( VAS 40-100mm) 4. with refractory knee pain to conventional treatment (such as muscle strength traing, biomechanical intervention, pharmacological treatments, intra-articular corticosteroids or hyaluronic acids) 5. not plan to undergo surgery within 3 months.

Exclusion criteria

Exclusion criteria: 1. Acute knee pain 2. Other connective tissue diseases (such as RA) 3. Serious neurologic or psychiatric disorders 4. Intra-articular injection with steroids or hyaluronic acids during the previous 3 months 5. Anticoagulant and/or antiplatelet medications 6. pacemakers 7. Prior electroacupuncture treatment 8. A person who are determined ineligible by the clinical investigator

Design outcomes

Primary

Measure	Time frame
Pain intensity using VAS, which were recorded at 12 weeks post procedure	—

Countries

Japan

Contacts

Public ContactHironobu Uematsu

Osaka University Graduate School of Medicine Department of Anesthesiology and Intensive Care Medicine

Uhironobu@anes.med.osaka-u.ac.jp06-6879-3133

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026