gastric cancer
Conditions
Interventions
intravenous acetaminophen(1000mg) for every 6 hours for 72 postoperative hours in conjunction with epidural analgesia after distal gastrectomy
epidural analgesia as standard treatment after dista
Sponsors
Digestive Disease Support Organization (DDSO)
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1) Histologically proven adenocarcinoma of the stomach 2) Surgically resectable tumor (cT1-4a, N0-3b, M0) by distal gastrectomy 3) Age 20 > years 4) ECOG performance status 0 or 1. 5) No prior treatment of chemotherapy or radiation therapy against any other malignancies. 6) Cases with adequately maintained organ functions and fullfilling the following conditions within 8 weeks before registration. WBC>3000 Plt>100000 AST<100 ALT<100 Total bilrbin<2.0mg/dL Serum creatinine<1.5mg/dL 7) Written informed consent
Exclusion criteria
Exclusion criteria: 1) Synchronous or metachronous (within 5 years) malignancies other than carcinoma in situ. 2) Inappropriate for epidural anesthesia 3) Infectious disease with a systemic therapy indicated. 4) Body temperature of 38C or more. 5) History of hypersensitivity of acetaminophen 6) History of hypersensitivity of aspirin-induced asthma 7) Severe mental disease. 8) Continuous systemic steroid therapy. 9) Unstable angina pectoris or history of myocardial infarction within 6 months. 10) Uncontrollable hypertension. 11) Uncontrollable diabetes mellitus 12) Severe respiratory disease requiring continuous oxygen therapy. 13) Women during pregnancy or breast feeding. 14) Judged inappropriate by the investigators
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The number of requiring rescue analgesics of edidural analgesia after surgery for 48 hours | — |
Countries
Japan
Contacts
Public ContactJun Kinoshita
Digestive Disease Support Organization (DDSO) Gastroenterologic surgery
Outcome results
None listed