Type 2 diabetes mellitus
Conditions
Interventions
Oral administration of 500-1000 mg metformin before test meal
Oral administration of 500-1000 mg metformin after test meal
Sponsors
Shiga University of Medical Science
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1) Aged >= 20, <70 at consent 2) In-patients with type2 diabetes at shiga universuty hospital with 500-1000 mg per single dose of metformin 3) Random non-fasting Triglyceride > 150mg/dl and < 1000mg/dl 4) Provided written informed consent
Exclusion criteria
Exclusion criteria: 1) Receiving drugs that affect gastrointestinal motility (Glucagon-like peptide-1 analogue, or anticholinergic drug, etc.) 2) Has history of pancreatitis 3) With severe autonomic dysfunction (orthostatic hypotension, or neurogenic bladder, etc.) 4) Has history of intestinal obstruction after upper gastrointestinal surgery or hepato-biliary-pancreatic surgery 5) Receiving treatment for cancers 6) During pregnancy or lactation 7) With contraindications to metformin (history of lactic acidosis, or moderate and severe renal impairment, etc.) 8) Considered inadequate by the investigator
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Changes in postprandial serum triglyceride concentrations between postprandial and preprandial administration | — |
Secondary
| Measure | Time frame |
|---|---|
| Changes of following parameters between postprandial and preprandial administration 1) plasma glucose, plasma insulin, GLP-1 2) Visual analyzing score of gastrointestinal symptoms and satiety | — |
Countries
Japan
Contacts
Public ContactKatsutaro Morino
Shiga University of Medical Science Department of Medicine, Division of Diabetes, Nephrology and Neurology
Outcome results
None listed