type 2 diabetes with serum uric acid levels more than 7 mg/dl and eGFR more than 60 mL/min/1.73m2
Conditions
Interventions
We measure clearance of para-aminohippurate and inulin in subjects had diabetes. after measurement,subjects take topiroxostat after breakfast and dinner twice a day for one week.And we measure cleara
Sponsors
Osaka City University Graduate School of Medicine
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1) Hyperuricemia 2) eGFR more than 60mL/min/1.73m2 3) diabees patients who were admitted to the Diabetes Center of the Osaka City University Hospital 4) The patients who were obtained written informed consent by free will after enough explanation.
Exclusion criteria
Exclusion criteria: 1) age more than 80 years or less than 20years 2) The patients who has malignant disease 3) The patients who has heavy heart failer or unstable angina 4) The patients who has heavy hepatic failer (AST or ALT more than 100U) 5) The patients who has renal failure 6) The patients who has past history of gout attack or who is already taking a therapeutic drug of the hyperuricemia 7) The patients who take a medicine which prohibited to taken with topiroxostat 8) Pregnancy planned woman,Pregnant woman,The woman whom I am nursing 9) The patient who has an allergy career to a study drug
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The change of measured GFR by topiroxostat (40 mg/day) administration in 7 days | — |
Secondary
| Measure | Time frame |
|---|---|
| Change in serum uric acid levels, albuminuria, xanthine oxidoreductase by topiroxostat(40mg/day) administration in 7 days | — |
Countries
Japan
Contacts
Public ContactAkihiro Tsuda
Osaka City University Graduate School of Medicine Department of Endocrinology, Metabolism and Molecular Medicine,
Outcome results
None listed