Role of blood cell mitochondria in heart failure

Role of blood cell mitochondria in heart failure - BLOODMITO-HF

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

JPRN

Registry ID

JPRN-UMIN000022564

Enrollment

Registered

2016-06-02

Start date

2016-06-03

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Heart failure

Interventions

None listed

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: Heart failure patients who have a history of hospital admission or who are hospitalized for worsening of heart failure

Exclusion criteria

Exclusion criteria: 1)Patients with active inflammation 2)Patients with malignant tumor 3)Patients who are receiving steroid or immunosuppressant

Design outcomes

Primary

Measure	Time frame
Mitochondrial respiratory capacity in blood cells	—

Secondary

Measure	Time frame
1)Mitochondrial oxidative stress originated from blood cells 2)Systemic inflammatory biomarkers 3)Systemic oxidative stress 4)Gene expression and protein synthesis regarding mitochondrial function, mitochondrial biogenesis, morphology, and inflammatory cytokines 5)Mitochondrial density in blood cells 6)Events (all-cause death, cardiac death, all-cause hospitalization, and hospitalization for worsening heart failure)	—

Measure

Time frame

1)Mitochondrial oxidative stress originated from blood cells 2)Systemic inflammatory biomarkers 3)Systemic oxidative stress 4)Gene expression and protein synthesis regarding mitochondrial function, mitochondrial biogenesis, morphology, and inflammatory cytokines 5)Mitochondrial density in blood cells 6)Events (all-cause death, cardiac death, all-cause hospitalization, and hospitalization for worsening heart failure)

—

Countries

Japan

Contacts

Public ContactTakashi Yokota

Faculty of Medicine and Graduate School of Medicine, Hokkaido University Cardiovascular Medicine

t-yokota@med.hokudai.ac.jp011-706-6973

Outcome results