Pneumothorax, Bullae, Benign lung tumors
Conditions
Interventions
A minimum of skin tissue and peripheral blood required for fibroblast sheets is collected from a research participant. A fibroblast sheet is doubly transplanted on to the site of lung air leaks after
Sponsors
Tokyo Women's Medical University
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1 A case of 20 years or older 2 The patients will undergo operation of lung resection and/or pleurectomy 3 A self-skin tissue is available for a cell processing without a functional invasive. 4 The functions of the main organs such as bone marrow, heart, liver, and kidney are kept. Within 2 weeks before registration, the criteria are follows. 1) White blood cell count >=3000mm3-<=12000mm3, 2) Neutrophil count >=1500mm3-<=5000mm3, 3) Hemoglobin >=8g/dL, 4) Platelet count >=50000mm3, 5) Aspartate aminotransferase (AST) and Alanine aminotransferase (ALT); 2.5 times upper limit of normal in our hospital, 6) Creatinine; 1.5 times upper limit of normal in our hospital 5 A case that a document agreement by the person himself was provided about examination participation.
Exclusion criteria
Exclusion criteria: 1 Patient with infectious disease (HBV, HCV, HIV, HTLV, syphilis) 2 Patients with the impossible of sealing of air leaks 3 Pregnancy and the possibility of the pregnancy 4 Patients with allergy (lidokin and antibiotics) 5 Patients with psychiatric diseases 6 Patients with skin diseases 7 Patients with severe or complicated medical conditions, not allowing participation into this protocol
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The safety of the autologous tissue engineered cell sheets | — |
Countries
Japan
Contacts
Public ContactRyo Takagi
Tokyo Women's Medical University Institute of Advanced Biomedical Engineering and Science
Outcome results
None listed