healthy volunteers
Conditions
Interventions
Exercise load with an ergometer bicycle continuing up to 50 min (VO2max 55%). PET scanning starts during the exercise loading and pharmacokinetic information of 11C-raclopride (dopamin D2 receptor) me
Sponsors
Tohoku University
University of Electro-Communications
Eligibility
Sex/Gender
Male
Inclusion criteria
Inclusion criteria: (1) right handed men with a habit of regular exercise of 1 or 2 days a week (2) those who were judged as suitable for the current study by physical strength tests
Exclusion criteria
Exclusion criteria: (1) abnormality of brain structure shown by MRI (2) any cardiac problems such as arrhythmia (3) severe allergy (4) regular administration of any therapeutic drugs
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| *binding potential values that is reflecting receptor density for dopamin D2 receptor (11C-raclopride) *binding potential values that is reflecting receptor density for histamine receptor (11C-doxepin) | — |
Secondary
| Measure | Time frame |
|---|---|
| *subjective feeling such as fatigue and frank measured with POMS as well as quality of life (QOL) *autonomic nervous function *blood chemistry (endocrine and immue) | — |
Countries
Japan
Contacts
Public ContactKazuko Takeda
Cyclotron and Radioisotope Center, Tohoku Univeristy Div. of Cyclotron Nuclear Medicine
Outcome results
None listed