Intrauterine administration of autologous peripheral blood mononuclear cells in patients with repeated implantation failure.

Intrauterine administration of autologous peripheral blood mononuclear cells in patients with repeated implantation failure. - Intrauterine administration of autologous PBMC in patients with RIF.

Status

Recruiting

Phases

Unknown

Study type

Interventional

Source

JPRN

Registry ID

JPRN-UMIN000022434

Enrollment

100

Registered

2016-06-15

Start date

2017-02-06

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

patients with repeated implantation failure

Interventions

Blood sampling and PBMC isolation on the day of oocyte retrieval. Incubate PBMC for two days. Fresh PBMC are obtained from the same patients 2 days after oocyte retrieval. After isolating PBMC, thes

Eligibility

Sex/Gender

Female

Inclusion criteria

Inclusion criteria: the patients with repeated implantation failure who performed embryo transfer more than 3times.

Exclusion criteria

Exclusion criteria: the patients whom an agreement is not obtained. the patient deviated from 18y.o. to 46y.o. the patient without the fertilized egg having good state.

Design outcomes

Primary

Measure	Time frame
Evaluations such as the grade of transplant embryo, the pregnancy rate and the delivery rate.	—

Countries

Japan

Contacts

Public ContactAsuka Okunomiya

Kyoto University Graduate School of Medicine Department of obstetrics and gynecology

okunoask@kuhp.kyoto-u.ac.jp075-751-3269

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026