Subjects with a tendency for constipation
Conditions
Interventions
Intake of a drink containing cocoa for 2 weeks, wash out for 2 weeks, Intake of a drink without cocoa for 2 weeks
Intake of a drink without cocoa for 2 weeks, wash out for 2 weeks, Intake of a drink c
Sponsors
QOL RD Co.,Ltd.
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: (1)Males and females from 20 to 60 years old (2)Subjects with a tendency for constipation at two to five times defecation per week (3)Healthy subjects with not taking any medicine (4)Subjects who can keep their stools in freeze immediately after defecation (5)Obtaining informed consent and signed a consent form
Exclusion criteria
Exclusion criteria: 1) Subjects with a serious liver, kidney, heart damage, diabetes, food allergies, digestive disorder, suffering other serious diseases 2) Subjects having medical history or operation history of digestive disorder 3) Subjects cannot keep the lifestyle 4) Subjects cannot regularly have three meals a day 5)Shifts workers or Late-night workers 6) Subjects whose amount of dietary intake or exercise has changed significantly 7) Subjects who donate either 400ml whole blood within 12 weeks or 200ml whole blood within 4 weeks or blood components within 2 weeks prior to this study. 8) Subjects who take any kind of medicine and/or food for specified health uses and/or supplements and/or diet foods 9) Subjects with drug and food allergies 10) Subjects with a hypersensitivity reaction to test food (eczema, nausea, diarrhea, etc.) 11) Subjects cannot ingest the test food as directed 12) Subjects who usually drink more than 500ml of beer in terms of per day 13) Subjects who take dietary fiber, fermented foods, foods containing a lot of lactic acid bacteria or bifidobacteria or another living bacteria or oligosaccharide or chocolate or cocoa 14) Subjects who will smoke during the test period 15) Subjects cannot wright a life diary everyday 16) Subjects who cannot avoid food intake, which influences on fecal odor, on the day before sampling feces 17) Subjects who participate other clinical trials or investigates in this trial 18) Subjects who are judged not applicable to this study by representative investigator or investigator
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Defecation frequency, fecal amount, fecal odor | — |
Secondary
| Measure | Time frame |
|---|---|
| Fecal conditions(fecal hardness, fecal color, fecal shape, feeling after defecation), fecal ammonia content, fecal putrefaction products content(indole, skatol) | — |
Countries
Japan
Contacts
Public ContactHaruka Yoshimoto
QOL RD Co.,Ltd. CRO Department Food Division
Outcome results
None listed