Association between coronary microvascular dysfunction and glycemic variability

Association between coronary microvascular dysfunction and glycemic variability - Association between coronary microvascular dysfunction and glycemic variability

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

JPRN

Registry ID

JPRN-UMIN000022404

Enrollment

Registered

2016-05-23

Start date

2015-06-10

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Ischemic heart disease

Interventions

Assessing the coronary microvascular function using a Certus Pressure Wire.

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: Patients with coronary artery disease who are undergoing coronary angiography 20 years of age or older Patients who have signed consent forms

Exclusion criteria

Exclusion criteria: Patients who are on diabetes medication Acute coronary syndrome Significant coronary stenosis in the left anterior descending artery (LAD) Prior myocardial infarction in the LAD territory Severe skin disease Severe blood disorder

Design outcomes

Primary

Measure	Time frame
Comparison of the index of microcirculatory resistance (IMR) between high MAGE (mean amplitude of glycemic excursions) and low MAGE patients. MAGE is measured by a continuous glucose monitoring system (CGMS).	—

Secondary

Measure	Time frame
Evaluating the relationship between coronary physiological measurements (IMR, coronary flow reserve [CFR], and fractional flow reserve [FFR]) and CGMS findings (mean glucose level, standard deviation of glucose levels, MAGE and hypoglycemia duration). Evaluating the relationship between coronary physiological measurements (IMR, CFR and FFR) and HbA1c, LDL cholesterol, HDL cholesterol, total cholesterol, triglyceride, body mass index, smoking status, renal function, hs-CRP, hs-troponin T and RHI. Comparison of coronary physiological measurements (IMR, CFR and FFR) between three groups: diabetes mellitus, impaired glucose tolerance and normal glucose tolerance.	—

Measure

Time frame

Evaluating the relationship between coronary physiological measurements (IMR, coronary flow reserve [CFR], and fractional flow reserve [FFR]) and CGMS findings (mean glucose level, standard deviation of glucose levels, MAGE and hypoglycemia duration). Evaluating the relationship between coronary physiological measurements (IMR, CFR and FFR) and HbA1c, LDL cholesterol, HDL cholesterol, total cholesterol, triglyceride, body mass index, smoking status, renal function, hs-CRP, hs-troponin T and RHI. Comparison of coronary physiological measurements (IMR, CFR and FFR) between three groups: diabetes mellitus, impaired glucose tolerance and normal glucose tolerance.

—

Countries

Japan

Contacts

Public ContactTakeshi Nishi

Chiba University Hospital Department of Cardiovascular Medicine

tnishi@chiba-u.jp043-222-7171

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026