Microvascular dysfunction in patients with valvular heart disease

Microvascular dysfunction in patients with valvular heart disease - Microvascular dysfunction in patients with valvular heart disease

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

JPRN

Registry ID

JPRN-UMIN000022401

Enrollment

Registered

2016-05-23

Start date

2015-06-10

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Valvular heart disease

Interventions

Cardiac catheterization study and mesurement of coronary microvascular function using Certus Pressure Wire for VHD and non-VHD patients

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: Clinically stable patients with valvular heart disease who are undergoing cardiac catheterization 20 years of age or older Patients who have signed consent forms

Exclusion criteria

Exclusion criteria: Significant stenosis in the left anterior descending artery (LAD), prior myocardial infarction in the LAD territory, acute decompensated heart failure, acute coronary syndrome, pregnancy

Design outcomes

Primary

Measure	Time frame
Evaluating the differences in the index of microcirculatory resistance (IMR) between patients with valvular heart disease (VHD group) and those without valvular heart disease (Non-VHD group)	—

Secondary

Measure	Time frame
Evaluating the differences in coronary flow reserve (CFR) and fractional flow reserve (FFR) between VHD group and Non-VHD group Comparing the number of abnormal IMR and abnormal CFR between VHD group and Non-VHD group Evaluating the relationship between IMR, CFR and FFR and the findings on cardiac catheterization and echocardiography Evaluating the relationship between IMR, CFR and FFR and clinical events Comparison of coronary physiological measurements (IMR, CFR and FFR) between groups divided according to ejection fractions or types of valvular heart disease (i.e. aortic stenosis, aortic regurgitation, mitral stenosis and mitral regurgitation) Evaluating the relationship between RHI and coronary physiological measurements (IMR, CFR and FFR) in the VHD group and non-VHD group.	—

Measure

Time frame

Evaluating the differences in coronary flow reserve (CFR) and fractional flow reserve (FFR) between VHD group and Non-VHD group Comparing the number of abnormal IMR and abnormal CFR between VHD group and Non-VHD group Evaluating the relationship between IMR, CFR and FFR and the findings on cardiac catheterization and echocardiography Evaluating the relationship between IMR, CFR and FFR and clinical events Comparison of coronary physiological measurements (IMR, CFR and FFR) between groups divided according to ejection fractions or types of valvular heart disease (i.e. aortic stenosis, aortic regurgitation, mitral stenosis and mitral regurgitation) Evaluating the relationship between RHI and coronary physiological measurements (IMR, CFR and FFR) in the VHD group and non-VHD group.

—

Countries

Japan

Contacts

Public ContactTakeshi Nishi

Chiba University Hospital Department of Cardiovascular Medicine

tnishi@chiba-u.jp043-222-7171

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026