patients who will undergo elective surgery of breast cancer
Conditions
Interventions
Just after arriving at operating room, patients received a bolus administration of tranexamic acid 10mg/kg(0.1ml/kg) and then infusion is continued at a rate of 2mg/kg/h(0.02ml/kg/h) until operation i
Sponsors
Department of Anesthesiology, Saitama Medeical Center, Saitama Medical University
Eligibility
Sex/Gender
Female
Inclusion criteria
Inclusion criteria: Female patients aged 20 to 80 years old and undergoing elective breast cancer surgery (American Society of Anesthesiologists physical status 1-2)
Exclusion criteria
Exclusion criteria: 1) drug allergy to tranexamic acid 2) patients with a history of preoperative sore throat, upper respiratory tract infection, common cold 3) patients who have cerebral infarction, coronary artery disease, venous thromboembolism 4) severe renal dysfunction(CKD stage more than 3) 5 patients who have dementia or cannot provide written informed consent signed by herself under her free will after receiving full explanation of the study 6) more than three attempt at intubation 7) patients who could not be intubated by laryngoscopy due to difficult airway
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Postoperative sore throat at 2,24 and 48 hours after leaving operation room | — |
Secondary
| Measure | Time frame |
|---|---|
| postoperative neusea and vomitting, postoperative wound pain, and postoperative urinary retention, | — |
Countries
Japan
Contacts
Public ContactKato Takao
Saitama Medeical Center, Saitama Medical University Department of Anesthesiology
Outcome results
None listed