Optimization of intravenous vancomycin treatment schedule for pediatric population with Monte Carlo Simulation

Optimization of intravenous vancomycin treatment schedule for pediatric population with Monte Carlo Simulation - Optimization of intravenous vancomycin treatment schedule for pediatric population with Monte Carlo Simulation

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

JPRN

Registry ID

JPRN-UMIN000022343

Enrollment

100

Registered

2016-05-19

Start date

2016-05-12

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Patients under 18 years old who were administered intravenous vancomycin in Department of Pediatrics or Department of Pediatric Cardiology in our institute between April 1st 2011 and March 31st 2016.

Interventions

None listed

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: Patients who were administered intravenous vancomycin in Department of Pediatrics or Department of Pediatric Cardiology between April 1st 2011 and March 31st 2016. Age under 18 years when vancomycin was initiated. Written informed consent is obtained.

Exclusion criteria

Exclusion criteria: Patients with renal dysfunction. Data unavailability exists. Lack of informed consent.

Design outcomes

Primary

Measure	Time frame
The proportion of the patients who achieved more than 400 of AUC/MIC in the present treatment strategy in our institute.	—

Secondary

Measure	Time frame
To compare the duration required for body temperature to be normalized between the populations with AUC/MIC above 400 and below 400. With Monte Carlo simulation, we will optimize the treatment strategy of vancomycin so that more than 90% of the patients achieve AUC/MIC more than 400.	—

Countries

Japan

Contacts

Public ContactReo Tanoshima

Yokohama City University Department of Pediatrics

tanotch@yokohama-cu.ac.jp(+81)45-787-2800

Outcome results