Effect of perioperative administration of a duloxetine on development of persistent postsurgical pain

Effect of perioperative administration of a duloxetine on development of persistent postsurgical pain - Duloxetine on persistent postsurgical pain

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

JPRN

Registry ID

JPRN-UMIN000022327

Enrollment

300

Registered

2016-05-16

Start date

2016-05-16

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Patients scheduled to undergo breast, thracic, orthopedic surgery

Interventions

Patients receive duloxetine 20 mg orally, 2 h before surgery, 20 mg once daily for the first 6 postoperative days. Patients receive placebo orally, 2 h before surgery, once daily for the first 6 posto

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: Patients scheduled to undergo breast, thoracic, orthopedic surgery.

Exclusion criteria

Exclusion criteria: Patients who have a pain around surgical site before surgery.

Design outcomes

Primary

Measure	Time frame
Incidence of persistent postsurgical pain at 3 months after surgery.	—

Countries

Japan

Contacts

Public ContactYuki Yoshiyama

Shinshu University School of Medicine Department of Anesthesiology and Resuscitology

yoshiyama@shinshu-u.ac.jp0263-37-2670

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026