Reflux esophagitis
Conditions
Interventions
There are three regimens as follows
(1) Vonoprazan 20mg once daily for 7 days, (2) Vonoprazan 10mg once daily for 7 days, (3) Vonoprazan 10mg and Lafutidine 10mg once daily for 7 days. Subujects receive the three different regimens in a
regimen (1), washout (at least 2 weeks), regimen (2), washout (at least 2 weeks), and regimen (3).
Interventions 2
regimen (1), washout (at least 2 weeks), regimen (3), washout (at least 2 weeks), and regimen (2).
Interventions 3
regimen (2), washout (at least 2 weeks), regimen (1), washout (at least 2 weeks), and regimen (3).
Interventions 4
regimen (2), washout (at least 2 weeks), regimen (3), washout (at least 2 weeks), and regimen (1).
Interventions 5
regimen (3), washout (at least 2 weeks), regimen (1), washout (at least 2 weeks), and regimen (2).
Interventions 6
regimen (3), washout (at least 2 weeks), regimen (2), washout (at least 2 weeks), and regimen (1).
Sponsors
First Department of Medicine and Center for Clinical Research, Hamamatsu University School of Medicine, Hamamatsu, Japan
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: Healthy Japanese men and women.
Exclusion criteria
Exclusion criteria: Exclusion criteria are any underlying disease, smoking habit, past or present H.pylori infection, and habitual use of any medicine.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The primary outcome is acid inhibition with the three regimens as assessed by 24-hour intragastric pH monitoring on Day7 in each regimen. | — |
Countries
Japan
Contacts
Public ContactTakahisa Furuta
Hamamatsu University School of Medicine Center for Clinical Research
Outcome results
None listed