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Effect of nitrous oxide on the cardiac autonomic system during anesthesia induction in preschool children

Effect of nitrous oxide on the cardiac autonomic system during anesthesia induction in preschool children - Nitrous oxide on autonomic function in children

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
JPRN
Registry ID
JPRN-UMIN000022288
Enrollment
40
Registered
2016-06-01
Start date
2016-06-10
Completion date
Unknown
Last updated
2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

anesthetized children

Interventions

N2O group. Anesthesia is induced using slowly-incremental doses of sevoflurane up to 5% in a gas mixture of nitrous oxide 4 l/min + oxygen 2 l/min. Once the complete loss of consciousness is obtained,

Sponsors

Tokyo Women's Medical University Yachiyo Medical Center Department of Anesthesiology
Lead Sponsor

Eligibility

Sex/Gender
All

Inclusion criteria

Inclusion criteria: 1) Subjects whose ages are equal to or older than 2 years old and younger than 7 years old. 2) Subjects who are planned to undergo minor surface surgery under general anesthesia such as inguinal hernia repair, orchidopexy, resection of fistula auris congenita, nevus resection, and laser diathermy of nevus pigmentosus 3) Subjects who do not suffer any systemic disease such as cardiovascular, respiratory, endocrine or metabolic diseases. 4) Subjects (the guardians) who give written informed consent

Exclusion criteria

Exclusion criteria: 1) Subjects who undergo emergency or sub-emergency surgery. 2) Subjects who suffer acute illnesses such as infectious diseases even after the approval from the guardians

Design outcomes

Primary

MeasureTime frame
Variables obtained by the frequency-domain analysis of the heart rate variablity; the power of low frequency component (0.04 - 0.15 Hz, LF), the power of high frequency component (0.15 - 0.5 Hz, HF), and the ratio LF/HF

Secondary

MeasureTime frame
mean blood pressure, heart rate

Countries

Japan

Contacts

Public ContactJiro Sato

Tokyo Women's Medical University, Yachiyo Medical Center Department of Anesthesiology

sato.jiro@nifty.com047-450-6000

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026