The effects of sleep inducing drugs on circulation

The effects of sleep inducing drugs on circulation - Sleep inducing drugs and circulation

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

JPRN

Registry ID

JPRN-UMIN000022248

Enrollment

Registered

2016-05-09

Start date

2016-06-21

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

healthy subjects

Interventions

To be taken Suvorexant 20mg at bedtime. At least 7 days are allowed between interventions. the order of interventions are randomized in each subjects. To be taken Brotizolam 0.25mg at bedtime. At leas

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: Healthy adult consented to participate in this study.

Exclusion criteria

Exclusion criteria: 1) Not satisfy selection criteria noted above. 2) Volunteers having allergic factors to foods and/or drugs.

Design outcomes

Primary

Measure	Time frame
cerebral autoregulation and baroreflex function at maximum drug concentration (Cmax) of sleep inducing drugs.	—

Secondary

Measure	Time frame
cerebral blood flow, arterial blood pressure, heart rate, stroke volume, respiratory condition, cerebral blood volume, cerebral metabolism, intracranial pressure.	—

Countries

Japan

Contacts

Public ContactYojiro Ogawa

Nihon University School of Medicine Division of Hygiene, Department of Social Medicine

ogawa.yojiro@nihon-u.ac.jp03-3972-8111

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026