valvular heart disease requiring valve replacement or valve plasty
Conditions
Interventions
A total 24 patients consist of the study population. These 24 patients are prospectively divided into the CS-CPB group and OS-CPB group in double blind fashion. Then, the patients will undergo cardiac
white blood cell, hemoglobin, hematocrit, platelet, serum creatinine, serum AST, serum ALT. Length of postoperative mechanical ventilation, ICU stay, occurrence of AKI, and intraoperative bleeding are
Sponsors
Saitama Medical Center, Jichi Medical University, Department of Cardiovascular Surgery
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: Those who undergo elective cardiac valve surgery in the Saitama Medical Center, Jichi Medical University, Saitama, Japan
Exclusion criteria
Exclusion criteria: 1) patients aged 49 years or younger 2) patients aged 76 years or older 3) patients who undergo surgical concomitant coronary artery revascularization or thoracic aortic surgery 4) patients who have preoperative liver dysfunction (AST > 30 IU/l and ALT > 30 IU/l) 5) patients who have chronic kidney diseae (serum creatinine level > 2.0mg/dl) 6) patients who have autoimmune disease 7) patients who are treated with steroid or other immune suppressing drug 8) patients who have blood disorder 9) patients in whom preoperative informed consent is difficult 10)patients who have decreased left ventricular function (left ventricular ejection fraction < 40%)
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 1. length of ICU stay 2. length of postoperative mechanical ventilation | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. postoperative WBC count 2. postoperaitve hemoglobin and hematocrit 3. postoperative serum creatinine 4. postoperative serum ASL/ALT (1-4;maximum value within 2 days of surgery) 5. postoperative acute kidney injury (assessed with AKIN classification) 6. intraoperative bleeding | — |
Countries
Japan
Contacts
Public ContactNaoyuki Kimura
Saitama Medical Center, Jichi Medical University Cardiovascular Surgery
Outcome results
None listed