Parkinson&
Conditions
Interventions
PD group, 200 mg caffeine administration, qd, 1 day
Control group, 200 mg caffeine administration, qd, 1 day
Sponsors
Department of Neurology, Juntendo University
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1) 40-60 years old when the informed consent is obtained. 2) Clinical stage: Hoehn and Yahr I or II 3) After having sufficient explanation, he/she agreed with joining in this research with his/her own informed consent form.
Exclusion criteria
Exclusion criteria: 1) >= 24 in Mini Mental State Examinations 2) Without heart disease, glaucoma or peptic ulcer. 3) Positive to past history of gasterointestinal surgery. 4) Presently having inflammatory bowel diseases, collagen vascular diseases, or bronchial asthma. 5) Having oral contraceptives. 6) Difficulty in withdraw caffeine intake just during 3 days before caffeine administration. 7) inappropriate cases who principle investigator identified.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| concentration changes of caffeine and its metabolites (in serum of pre-administration and 0.5 h, 1 h, 2 h, 4 h and 6 h after administration of caffeine) | — |
Countries
Japan
Contacts
Public ContactShinji Saiki
Juntendo University Department of Neurology
Outcome results
None listed