metastatic colorectal cancer
Conditions
Interventions
None listed
Sponsors
West Japan Oncology Group
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1.Histologically documented metastatic measurable adenocarcinoma of the colorectum with no prior chemotherapies for metastatic disease.The case with liver metastase 2.Age: >20, <75. 3.ECOG PS of 0 or 1. 4.Adequate hematologic, renal, and hepatic function as defined by required baseline laboratory parameters. 5.Written informed consent.
Exclusion criteria
Exclusion criteria: 1.Brain metastasis with symptoms. 2.Massive asites, pleural effusion or pericardial effusion. 3.Double cancer with in five years prior to enroll in this study. 4.Serious non-healing wound. 5.Major surgical procedure within 28 days prior to enroll in this study. 6.Minor surgical procedure within 14 days prior to enroll in this study. 7.Other serious concomitant disease. 8.Regular use of corticosteroid. 9.Regular use of anticoagulation therapy. 10.Peripheral neuropathy > Grade 1 at baseline. 11.Active infectious disease. 12.History of serious hypersensitivity. 13.Hepatitis B surface antigen. 14.Mental disorder. 15.Pregnant or nursing.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Correlation between morphologic response and progression-free survival | — |
Secondary
| Measure | Time frame |
|---|---|
| Correlation between morphologic response and overall survival | — |
Countries
Japan
Contacts
Public ContactShinichiro Nakamura
West Japan Oncology Group WJOG datacenter
Outcome results
None listed