Staged gamma knife radiosurgery for patients with large brain metastases: A multi-institutional retrospective study

Staged gamma knife radiosurgery for patients with large brain metastases: A multi-institutional retrospective study - Staged gamma knife radiosurgery for patients with large brain metastases

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

JPRN

Registry ID

JPRN-UMIN000022152

Enrollment

300

Registered

2016-04-30

Start date

2016-05-01

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Metastatic brain tumors

Interventions

None listed

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: Patients having metastatic brain tumors treated with staged gamma knife radiosurgery until end of December 2015. The included patients meet the following criteria: 1) newly diagnosed brain metastases 2) maximum total treatment period of 6 weeks 3) minimum interval between fractions of 12 days 4) Prescribed dose 9-11 Gy for 3 staged or 11.8-14.3 Gy for 2 staged gamma knife radiosurgery 5) KPS more than and equal to 70, or KPS less than 70 due to neurological symptom 6) maximum volume of 33.5 cm3 7) up to 10 brain tumors 8) maximum total tumor volume of 50 cm3 9) patient&#39;s head secured with Leksel G frame 10) no finding of meningeal seeding or carcinomatous meningitis on MRI 11) one or more available follow-up MRI

Exclusion criteria

Exclusion criteria: Patients with brain tumors of unknown origin, brain metastases of sarcoma, malignant lymphoma are excluded in this study.

Design outcomes

Primary

Measure	Time frame
Overall survival	—

Secondary

Measure	Time frame
1) Functional preserved survival 2) Additional treatments 3) Local tumor control 4) Treatment-related adverse events	—

Countries

Japan

Contacts

Public ContactYoshinori Higuchi

Chiba University Graduate School of Medicine Department of Neurological Surgery

yhiguchi@faculty.chiba-u.jp043-226-2158

Outcome results