Bipolar depression
Conditions
Interventions
Low-frequency right prefrontal transcranial magnetic stimulation for 4 weeks
Sponsors
National Center Hospital, National Center of Neurology and Psychiatry
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. DSM-5 diagnosis of bipolar disorder, major depressive disorder 2. HAMD 17 score >= 18 3. Current episode duration < 3 y 4. Patient does not respond to the medications described below for more than 8 weeks. i. Lithium, 0.8mmol/L ii. Quetiapine, 300mg/day iii. Olanzapine, 5-20mg/day iv. Lamotrigine, 200mg/day
Exclusion criteria
Exclusion criteria: 1. Rapid cycler type 2. Patient has a history of psychotic episode, OCD, PTSD, and eating disorder. 3. Patient had a previous treatment with ECT, TMS, VNS, DBS, and tDCS within 6 months. 4. Patient did not respond to ECT and TMS previously. 5. Pregnancy 6. Patient has a history of epilepsy and convulsion. Personal or close family history of seizure disorder 7. Neurologic disorder, organic brain disease 8. Substance or alcohol dependence 9. Ferromagnetic material in body or close to head 10. Severe metabolic disease, endocrine disease 11. Active suicide idea 12. Taking medications known to lower seizure threshold
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Changes in the total score of Hamilton&#39;s Rating Scale for Depression (HAMD 17 items) at week 4 | — |
Countries
Japan
Contacts
Public ContactShinsuke Kito
National Center of Neurology and Psychiatry Department of Psychiatry and Advanced Medical Technology
Outcome results
None listed