Healthy volunteers
Conditions
Interventions
2 test foods per day for 12 weeks
2 placebo foods per day for 12 weeks
Sponsors
TTC CO., LTD.
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: (1) Males aged 45 to less than 69 years old or Females aged 55 to less than 69 years old. (2) Choosing subjects who judged it when the investigators are qualified among BMI of advance examination, girth of the abdomen, blood pressure, laboratory evidence and aim for the examination before intake. (3) Subjects whose screening value of baPWV is more than 1,400 cm/sec in right or left arm.
Exclusion criteria
Exclusion criteria: (1) Subjects who intake supplement and/or health foods, nutrition supplement, medicine, quasi-drug containing amino acid at advance examination. (2) Subjects who constantly eat watermelon at advance examination (e.g., more three times per week) (3) Subjects who constantly intake health foods and/or supplement or medicine, quasi-drug which may have vascular function improvement effect at advance examination (e.g., CoQ10, Nattokinase, Lutein, blueberry, Cassis, Vitamin E, Ginkgo leaf extract, melilot, Hesperidin as the polyphenols, Flavangenol, Pycnogenol) (4) Subjects having possibilities for emerging allergy related to the study. (5) Subjects who smoke at advance examination (including subjects who started smoking cessation within pre-three months at the time of advance examination) or hope smoking during study duration. (6) Subjects who ABI less than 0.90 at advance examination. (7) Subjects who have a history of serious disease (e.g., diabetes, liver disease, kidney disease, heart disease, cerebrovascular disease, malignant, anomaly of aminoacid metabolism, arrhythmia) (8) Subjects having a disease requiring treatment. (9) Subjects with a disease under treatment. (10) Subjects who are judged as unsuitable for the current study based on the results of clinical and physical preliminary examination. (11) Subjects who have a lifestyle affect the result of this study (ex. work on midnight shift) or subjects who are going to change to a lifestyle affect the result of this study (ex. work on midnight shift) (12) Subjects with a disease under treatment. (13) Subjects who are judged as unsuitable for the current study based on the results of lifestyle questionnaire. (14) Subjects who have participated in other clinical studies within the last one month prior to the current study or are planned to participate in other studies after obtaining informed consent for the current study. (15) Subjects judged as unsuitable for the current study by the investigator.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| baPWV(brachial-ankle pulse wave velocity)(0,12 weeks) | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. FMD(flow-mediated dilatation) 2. ABI(ankle brachial index) 3. blood NOx(Nitrate+Nitrite) 4. blood amino acid concentration 5. ADMA(AsymmetricDimethylarginine) 6. SDPTG(second derivative of photoplethysmogram) 7. vascular age 8. VAS questionnaire | — |
Countries
Japan,South America
Contacts
Public ContactSaki Fukuchi
TTC CO., LTD. Clinical Research Planning Department
Outcome results
None listed