Healthy adults
Conditions
Interventions
1)Irradiation of UVB on inner side of upper arms for two straight days 2)Apply the physical therapy and placebo therapy for 8weeks after 1week from irradiation of UVB. These therapies will take 3hour
Sponsors
Kao Corporation
Eligibility
Sex/Gender
Male
Inclusion criteria
Inclusion criteria: -Healthy males
Exclusion criteria
Exclusion criteria: -Subjects with cutaneous symptoms of atopic dermatitis -Subjects with clinically-significant disorder (wound and eczema etc.) at the test site - Subjects who suffer from heat urticaria -Subjects who play outdoor activities with excessive sunburn routinely -Subjects with excess sunburn at the test site -Subjects who take daily application of medicine such as hormone preparation and cosmetics, and medicine for melanosis (chloasma, pigmented spots etc.) -Subjects who see a doctor regularly or had a routine visit to a clinic within the past 1 month for disease (gastrointestinal system, liver, kidney, heart, blood pressure, skin, and physical deconditioning). (Manual therapy, chiropractic and massage are not included) -Subjects who suffer from disease relevance to vascular function (hypertension, heart disease, diabetes mellitus, Raynaud disease, rosacea, telangiectasia) and severe feeling of cold -Subjects who had trouble in electrocardiography in the past (abnormal cardiac rhythm) -Subject who are taking OTC or prescription medicine( ex. hypnotic, anti-allergic agent, hormone preparation, cathartic, intestinal regulator, and others) -Subjects known or suspected to be drug allergy -Subjects who habitually take much (over three cups per day) coffee per day -Subjects who smoke -Subjects who participated in another clinical study accompanied by topical application of formulations and tape stripping treatment to the site to be studied within the past 1month -Subjects deemed inappropriate to participate in this study by the principle investigator
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| -Change of stratum corneum water content after 1, 5, and 9 weeks intervention. -Change of trans epidermal water loss after 1, 5, and 9 weeks intervention. -Change of skin color after 1, 5, and 9 weeks intervention. -Change of skin viscoelasticity after 1, 5, and 9 weeks intervention. -Change of skin shape after 1, 5, and 9 weeks intervention. -Change of vascular function after 1, 5, and 9 weeks intervention. | — |
Countries
Japan
Contacts
Public ContactYoshie Shimotoyodome
Kao Corporation R&D -Core Technology- Biological Science Research
Outcome results
None listed