Novel approach for elucidating pathophysiology in patients with acute lacuna stroke

Novel approach for elucidating pathophysiology in patients with acute lacuna stroke - Novel approach for elucidating pathophysiology in patients with acute lacuna stroke

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

JPRN

Registry ID

JPRN-UMIN000022057

Enrollment

Registered

2019-03-31

Start date

2016-04-25

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

acute lacuna stroke

Interventions

None listed

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: Within 48 hours after the stroke onset. Premorbid mRS is 2 or below 2. Lacuna patients whose responsible lesion is perforator areas diagnosed by MRI.

Exclusion criteria

Exclusion criteria: Stroke patients whose responsible lesions were brainstem or cerebellar. Patients who cannot be undergone examination of MRI.

Design outcomes

Primary

Measure	Time frame
Correlation between cerebral blood flow and metabolism by positron emission tomography and parameters of tractgraphy by diffusion tensor imaging at the 2 points, such as 10 days and 3-6 months after the stroke onset.	—

Secondary

Measure	Time frame
Changes of the levels of serum biomarker, such as D-dimer,fibrinogen,thrombin antithrombin complex, soluble intercellular adhesion molecule-1, interlukin-6, and tumor necrosis factor. Analysis of Neurite orientation dispersion and density imaging (baseline, 3 months)	—

Countries

Japan

Contacts

Public ContactChiaki Yokota

National Cerebral and Cardiovascular Center Cerebrovascular Rehabilitation

cyokota@ncvc.go.jp06-6833-5012

Outcome results