Parkinson'
Conditions
Interventions
Oral administration of istradefilline 20mg / day for 12-week. If the improvement of wearing off is insufficient after 4 weeks, it is possible to increased to 40mg / day.
Sponsors
Nippon Medical School
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: The patients who have akinesia with regidity or tremor and diagnosed as Parkinson's disease. The patients presenting wearing-off phenomenon. The patients with 3 points or more in Snaith-Hamilton Pleasure Scale Japanese version or 16 points or more in Apathy Scale or 14 points or more in Beck Depression Inventory-II. The patients with 23 points or more in Mini Mental State Examination.
Exclusion criteria
Exclusion criteria: The patients who are expected to change anti-parkinsonian drugs during the study. The patients who have marked psychiatric fluctuation. The patients who take the following agents: ketoconazole, Rifampicin, midazolam, atorvastatin or digoxin. The patients with current smoker.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The changes of score in depresion-related-scales. | — |
Secondary
| Measure | Time frame |
|---|---|
| The changes of score in Parkinson's disease disease-related-scales. | — |
Countries
Japan
Contacts
Public ContactHiroshi Nagayama
Nippon Medical School Neurology
Outcome results
None listed