Potassium-competitive acid blocker versus proton pump inhibitor for the healing effect of gastric ulcer induced by endoscopic submucosal dissection

Potassium-competitive acid blocker versus proton pump inhibitor for the healing effect of gastric ulcer induced by endoscopic submucosal dissection - Comparison of vonoprazan and lansoprazole

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

JPRN

Registry ID

JPRN-UMIN000022006

Enrollment

Registered

2016-04-22

Start date

2015-08-19

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

early gastric cancer

Interventions

Patients were prospectively and randomly assigned into either vonoprazan group or lansoprazole group. The day before ESD, patients were admitted. After the ESD,patients in vonoprazan group began to ta

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: Thirty consecutive patients, who underwent ESD for early gastric cancer between August 2015 and March 2016 at Sado General Hospital, were enrolled in this study. Patients who had undergone gastric surgery before ESD were not included in this study.

Exclusion criteria

Exclusion criteria: Those who needed any additional anticancer therapy (surgery and/or chemotherapy) after ESD were excluded.

Design outcomes

Primary

Measure	Time frame
The primary endpoint was to evaluate the shrinking rate of ESD-induced ulcers between vonoprazan (20mg/day) group and lansoprazole (30mg/day) group 28 days after ESD.	—

Secondary

Measure	Time frame
The secondary endpoint was to compare the preventive effect of vonoprazan and lansoprazole for delayed bleeding	—

Countries

Japan

Contacts

Public ContactKazuya Takahashi

Niigata University Medical and Dental Hospital, Niigata, Japan Division of Gastroenterology and Hepatology

kazuya911@hotmail.co.jp025-223-2207

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026