Retinitis Pigmentosa
Conditions
Sponsors
Chiba university Department of Ophthalmology
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: Patients who meet all of the following criteria at least one eye 1)typical retinitis pigmentosa patients (less than 20 years of age or 80 years of age) 2)2 times of reliability that was performed within 31 days (fixation failure rate of less than 20%, the false positive rate of less than 15%, false-negative rate of less than 33%) static perimetry (HFA) 10-2 center four points with the average difference in the retina sensitivity is within 3dB, and also less than 30dB any of the value 3)Patient decimal vision of 0.01-0.4 4)Patients with afferent visual field constriction of 10 degrees or less in the 1 / 4 of the Goldman visual field examination (Gp) 5)Patient HFA10-2 of Mean Deviation (MD) value is less than -15dB 6)Patients after receiving a sufficient explanation Upon participation in the present study, after an adequate understanding, the document agreed by the free will of the patient himself was obtained
Exclusion criteria
Exclusion criteria: Patients conflict with one of the following: 1)Patients with vitreous macular traction syndrome, macular edema, epiretinal membrane, macular lesions such as high myopia with posterior staphyloma 2)Patients undergoing eye surgery within three months 3)Patients who use isopropyl unoprostone, calcium antagonist, dark adaptation improving agent within 31 days 4)Patient with a history of drug allergy for mydriatic, such as eye drops anesthetic that we plan to use during the trial period 5)Patients who are complicated by diabetic retinopathy 6)patients with merging inflammation external eye, infections, or severe dry eye 7)Patients likely to have been pregnant or pregnant. Patients during breast-feeding. Patients who wish to become pregnant during the study period 8)Patients with a history of optic nerve disease 9)Patients with merger moderate (grade3 of Emery classification) or more of nuclear cataract, serious affect such pre subcapsular cataract, posterior subcapsular cataract or secondary cataract in vision
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Safety (adverse events such as decrease of visual function, skin disorders) Evaluated at the time of 1 hour, 1 week, 2 weeks, and 4 weeks after the end of the treatment | — |
Secondary
| Measure | Time frame |
|---|---|
| 1:visual acuity 2:Retinal sensitivity 3:electroretinogram 4:Optical coherence tomography 5:Visual field 6:Quality of vision | — |
Countries
Japan
Contacts
Public ContactGen Miura
Chiba university Department of Ophthalmology
Outcome results
None listed