Study the role of water channels in human bladder epithelium involved in water re-absorption function

Study the role of water channels in human bladder epithelium involved in water re-absorption function - Study the role of water channels in human bladder epithelium

Status

Recruiting

Phases

Unknown

Study type

Interventional

Source

JPRN

Registry ID

JPRN-UMIN000021854

Enrollment

Registered

2016-04-10

Start date

2016-05-01

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

overactive bladder

Interventions

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: Patients who underwent cystectomy against bladder cancer in our hospital

Exclusion criteria

Exclusion criteria: Not applicable

Design outcomes

Primary

Measure	Time frame
At our hospital we perform total bladder cystectomy for bladder cancer, and from the specimen we pick up, we can gather parts that are considered macroscopically normal tissue. In the collected tissues, the presence and the structure of aquaporin 3 and aquaporin 1, whose presence is predicted in human bladder tissue, existence and structure are confirmed at the collaborative research institution at the histological and electron microscopic level . Especially, normal bladder tissues immediately after removal are loaded into the Ussing chamber and the functions and control mechanisms of the sodium ion channel / chloride ion channel / water channel are clarified. Furthermore, in order to confirm whether the tissue used in this study is a normal tissue, some specimens for tissue diagnosis are also stored at the time of tissue collection.	—

Measure

Time frame

At our hospital we perform total bladder cystectomy for bladder cancer, and from the specimen we pick up, we can gather parts that are considered macroscopically normal tissue. In the collected tissues, the presence and the structure of aquaporin 3 and aquaporin 1, whose presence is predicted in human bladder tissue, existence and structure are confirmed at the collaborative research institution at the histological and electron microscopic level . Especially, normal bladder tissues immediately after removal are loaded into the Ussing chamber and the functions and control mechanisms of the sodium ion channel / chloride ion channel / water channel are clarified. Furthermore, in order to confirm whether the tissue used in this study is a normal tissue, some specimens for tissue diagnosis are also stored at the time of tissue collection.

—

Countries

Japan

Contacts

Public ContactTakeshi Nomura

Kyoto Prefectural University of Medicine Urology

takeshi@koto.kpu-m.ac.jp075-251-5595

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026