Treatment response of chemotherapy in patient with lung cancer:evaluation of tumor blood flow using H215O-PET/CT

Treatment response of chemotherapy in patient with lung cancer:evaluation of tumor blood flow using H215O-PET/CT - evaluation of tumor blood flow using H215O-PET/CT

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

JPRN

Registry ID

JPRN-UMIN000021847

Enrollment

Registered

2016-04-10

Start date

2011-10-07

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

lung cancer

Interventions

Radioactive water (370MBq) is injected intravenously before PET/CT.

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: The patients who are planned to receive chemotherapy at our institution and agree to enter the present study.

Exclusion criteria

Exclusion criteria: The Patients who do not agree to enter the present study and have problems with hemostatic function.

Design outcomes

Primary

Measure	Time frame
H215O-PET/CT is performed on the basis of the protocol which has been reported on Journal of Nuclear Medicine 2010;51:1684-1690. H215O-PET/CT is performed before and about 1 to 3 days after chemotherapy. Tumor perfusion (F)is calculated by using the following the standard single-tissue compartment model. The therapy response using F value is compared with that using the therapy response using RECIST criteria.	—

Measure

Time frame

H215O-PET/CT is performed on the basis of the protocol which has been reported on Journal of Nuclear Medicine 2010;51:1684-1690. H215O-PET/CT is performed before and about 1 to 3 days after chemotherapy. Tumor perfusion (F)is calculated by using the following the standard single-tissue compartment model. The therapy response using F value is compared with that using the therapy response using RECIST criteria.

—

Secondary

Measure	Time frame
The time-dependent change in radioactivity concentration of tumor and in radioactivity concentration of radial artery are evaluated. We investigate whether the artrial time-activity curve calculated from PET/CT can be substituted for the radioactivity concentration of radial artery or not.	—

Countries

Japan

Contacts

Public ContactJun Hatazawa

Osaka University Graduate School of Medicine Nuclear Medicine and Tracer Kinetics

hatazawa@tracer.med.osaka-u.ac.jp06-6879-3461

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026