gastroesophageal reflux disease
Conditions
Interventions
encoscopic submucosal dissection
Sponsors
Osaka Medical College
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. Males or females aged 20 years or older 2. Patients complaining of symptoms of gastroesophageal reflux disease on an inquiry sheet despite receiving PPI therapy for 8 weeks or more 3. Those with reflux esophagitis involving <3/4 of the circumference on endoscopy 4. Those in whom intra-esophageal pressure measurement and 24-hour esophageal pH monitoring were performed before surgery, and endoscopy, intra-esophageal pressure testing, and 24-hour esophageal pH monitoring are possible 1 month after surgery 5. Those from whom written informed consent regarding this procedure was obtained
Exclusion criteria
Exclusion criteria: 1. Patients aged 19 years or younger 2. Those with reflux esophagitis involving more than 3/4 of the circumference on endoscopy 3. Those with a history of portal hypertension or esophageal varices 4. Those who have undergone gastric or esophageal surgery 5. Those with esophagostenosis or dysphagia
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The primary endpoint was the improvement in the rate of heartburn experienced by the patients following ESD-G. | — |
Secondary
| Measure | Time frame |
|---|---|
| The secondary endpoints were comparisons of the frequency scale for the symptoms of GERD (FSSG), before and 6 months after the procedure, oral medication dose, LA classification of the endoscopic findings, and esophageal 24-h pH monitoring. The safety of ESD-G was also assessed. | — |
Countries
Japan
Contacts
Public ContactToshihisa Takeuchi
Osaka Medical College Endoscopy Center
Outcome results
None listed