[18F]THK-5351 PET imaging of tau deposits in neurological disorders

[18F]THK-5351 PET imaging of tau deposits in neurological disorders - [18F]THK-5351 PET imaging in neurological disorders

Status

Recruiting

Phases

Unknown

Study type

Interventional

Source

JPRN

Registry ID

JPRN-UMIN000021819

Enrollment

160

Registered

2016-05-01

Start date

2017-01-27

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

corticobasal syndrome, other neurodegenerative disorders, and normal volunteers

Interventions

After injecting 185 MBq of 18F-THK5351, PET images were obtained and were used for the evaluation of group differences.

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: 1) Probable CBS are diagnosed based on the modified Cambridge criteria. 2) Written informed consent are obtained from each patient or their guardians after being given a complete description of the study.

Exclusion criteria

Exclusion criteria: 1) neuropsychiatric disorder except for corticobasal syndrome 2) severe cardiovascular disease or liver dysfunction

Design outcomes

Primary

Measure	Time frame
[18F]THK-5351 uptake in frontal and parietal cortexes of corticobasal syndrome	—

Secondary

Measure	Time frame
[18F]THK-5351 uptake in subcortical white matter or brainstem of corticobasal syndrome	—

Countries

Japan

Contacts

Public ContactAkio Kikuchi

Tohoku University Graduate School of Medicine Department of Neurology

akikuchi@med.tohoku.ac.jp022-717-7189

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026