All of diseases that oral medication is prescribed
Conditions
Interventions
All the volunteers will taste 9 and 7 samples including water in order to investigate the threshold concentration of quinine hydrochloride and loperamide hydrochloride for the recognition of bitternes
Sponsors
Intelligent Sensor Technology, Inc.
Medical and Health Resources Research Institute
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: Healthy female and male adult
Exclusion criteria
Exclusion criteria: 1. People who are not like degustation 2. People who are allergic to drugs (quinine hydrochloride, loperamide hydrochloride) 3. people not eligible by the discretion of the investigator
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| A filter paper wetted with bitter substance will be placed on the tongue of volunteers and the strength of bitterness will be measured within 1 minute. After rinsing thoroughly in the mouth with water, then strengths of bitterness of quinine hydrochloride and loperamide hydrochloride will be measured. | — |
Secondary
| Measure | Time frame |
|---|---|
| In each volunteer, the concentration of loperamide hydrochloride which produces the same bitterness of quinine hydrochloride at 30 times higher concentration of the threshold value. | — |
Countries
Japan
Contacts
Public ContactJun Kojima, PhD.
Medical and Health Resources Research Institute No
Outcome results
None listed