Examination of the acotiamide effect on reflux symptom in patients with proton pump inhibitor-resistant non-erosive- gastroesophageal reflux disease with the functional dyspepsia symptom. -A randomized, double-blind,placebo-controlled,crossover studt-

Examination of the acotiamide effect on reflux symptom in patients with proton pump inhibitor-resistant non-erosive- gastroesophageal reflux disease with the functional dyspepsia symptom. -A randomized, double-blind,placebo-controlled,crossover studt- - Examination of the acotiamide effect on reflux symptom in patients with PPI resistant NERD with the functional dyspepsia symptom

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

JPRN

Registry ID

JPRN-UMIN000021787

Enrollment

Registered

2016-04-06

Start date

2016-04-06

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Effect on reflux symptom in patients with proton pump inhibitor-resistant non-erosion-related gastroesophageal reflux disease with the functional dyspepsia symptom

Interventions

It is the placebo group from the Ako thiamide group It is the Ako thiamide group from the placebo group

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: The PPI-resistant NERD patients with the FD symptom

Exclusion criteria

Exclusion criteria: Serious complications

Design outcomes

Primary

Measure	Time frame
Four weeks later, we weigh it against GERD symptom (FSSG) in QOL(SF-36,GSRS) if before internal use.	—

Secondary

Measure	Time frame
Of FD symptom (FD score of FD interview ,FSSG) and the esophagus clearance weigh.	—

Countries

Japan

Contacts

Public ContactYasushi Funaki

Aichi Medical University Division of Gastroenterology

momomaru@aichi-med-u.ac.jp0561-62-3311

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026